The Complutensian Polyglot Bible, published in 1517, was the first printed polyglot Bible, featuring parallel texts in Hebrew, Greek, Latin, and Aramaic. Produced under the direction of Cardinal Francisco de Cisneros in Alcalá de Henares, Spain, this monumental work represented a significant advancement in biblical scholarship and accessibility. It aimed to provide scholars and clergy with a comprehensive resource for studying the Scriptures in their original languages. The publication played a crucial role in the Reformation and the rise of textual criticism.

The publication of the Complutensian Polyglot Bible in 1517 advanced biblical scholarship and translation efforts, inspiring humanist poets like Erasmus. Its influence permeated 16th-century verse, leading to a resurgence of scriptural allusions and themes of divine inspiration in poetry.