In 1274, the principles of alchemy began to spread more widely across Europe, influenced by earlier Islamic scholars. This blend of mysticism and proto-science sought to transform base metals into gold and discover the elixir of life. Alchemy's popularity during this period laid the groundwork for later scientific inquiry and philosophical exploration.

Alchemy's themes of transformation and the quest for knowledge resonated deeply with poets and writers, inspiring works that explored the intersection of science and spirituality. Poets like John Milton would later incorporate alchemical imagery and symbolism into their writings, reflecting the era's fascination with transformation and the mysteries of existence.