In 1301, the practice of alchemy was gaining popularity in Europe, influenced by earlier Islamic scholars. Alchemists sought to transform base metals into gold and discover the philosopher's stone, symbolizing the quest for knowledge and enlightenment. This interest in alchemy contributed to the development of early chemistry and the scientific method.

The themes of transformation and the quest for knowledge in alchemy influenced poets and writers, inspiring works that explored the mystical and philosophical aspects of existence. Poets like John Milton later drew upon alchemical imagery to convey deeper meanings in their poetry.