In 1314, alchemical practices were becoming more established in Europe, blending science, philosophy, and mysticism. This pursuit of transforming base metals into gold and discovering the elixir of life reflected the era's fascination with the natural world and the quest for knowledge. Alchemy played a crucial role in the development of modern chemistry.

Alchemical themes began to appear in poetry, symbolizing transformation, knowledge, and the quest for meaning. Poets like John Milton later drew upon these themes, using alchemical imagery to explore deeper philosophical questions in their works.