In 1564, Italian anatomist Gabriele Falloppio published a description of a linen condom designed to prevent syphilis, which he tested on 1,100 men. This early form of contraception represented a significant advancement in sexual health practices during the Renaissance. Falloppio's work contributed to the understanding of disease prevention and laid the groundwork for future developments in sexual health.

Gabriele Falloppio's description of the linen condom for syphilis prevention influenced Renaissance poetry that grappled with themes of love, disease, and bodily risk. This early medical endorsement shaped a discourse on protection and vulnerability in romantic relationships.