The extinction of the Cuban crocodile's mainland population in 2000 was primarily driven by habitat loss and hybridization with the American crocodile. This decline highlights the fragility of ecosystems and the impact of human activity on wildlife. The loss of this population serves as a stark reminder of the importance of conservation efforts to protect endangered species and their habitats from further degradation.

The extinction of the Cuban crocodile mainland population in 2000 was reflected in Caribbean poetry that addressed themes of environmental degradation and isolation. Poets like Nancy Morejón and José Martí used their works to advocate for conservation and cultural identity.