Jesuit missionaries undertook Guarani Bible translation completed around 1760, working with Guarani scholars in Paraguay and Argentina. Jesuits created Guarani orthography, grammar books, and established Guarani printing presses. Their missionary linguistics uniquely emphasized Guarani language preservation rather than Spanish imposition. This translation occurred during Spanish colonial period before 1767 Jesuit expulsion. Guarani Bible became foundation for Guarani literary development and religious poetry among Guarani-speaking communities, preserving Guarani language as living literature.

Guarani Bible translation established Guarani Christian literary vocabulary, enabling Guarani Christian poetry adapting traditional Guarani poetic forms for Christian themes. The Jesuit linguistic approach preserved Guarani as living literary language unlike many conquered indigenous languages. Guarani Bible became foundation for Christian Guarani literary tradition, with Guarani remaining official language in Paraguay alongside Spanish, unique among indigenous South American languages.