In 1248, the Order of the Knights of the Hospital of Saint John of Jerusalem was officially recognized, playing a significant role in the Crusades and the care of the sick. Based in Rhodes, this order contributed to the cultural and religious dynamics of the time, providing medical care and protection for pilgrims. Their establishment marked a notable moment in the intersection of chivalry, religion, and healthcare during the medieval period.

The Knights of Saint John inspired numerous literary works that romanticized chivalry and the ideals of knighthood. Poets and writers often depicted the valor and compassion of these knights, influencing the narrative style of medieval literature. Their stories contributed to the development of heroic poetry, emphasizing themes of bravery, sacrifice, and the moral complexities of war.