In 1254, alchemy was gaining popularity in Europe as a precursor to modern chemistry, blending philosophical and mystical elements. Alchemists sought to transform base metals into gold and discover the elixir of life, with significant centers of study in cities like Paris and Bologna. This intellectual pursuit influenced various fields, including literature and the arts.

The themes of transformation and the quest for knowledge in alchemy resonated with poets and writers, inspiring works that explored the human condition and the nature of existence. Alchemical symbolism can be found in the poetry of figures like John Milton and later Romantic poets, who often grappled with the interplay of science and spirituality.